Malicious codes have been widely documented and detected in information security breach occurrences of Microsoft Windows platform. Legacy information security systems are particularly vulnerable to breaches, due to Window kernel-based malicious codes, that penetrate existing protection and remain undetected. To date there has not been enough quality study into and information sharing about Windows kernel and inner code mechanisms, and this is the core reason for the success of these codes into entering systems and remaining undetected. This paper focus on classification and formalization of type target and mechanism of various Windows kernel-based attacks, and will present suggestions for effective response methodologies in the categories of, "Kernel memory protection", "Process & driver protection" and "File system & registry protection". An effective Windows kernel protection system will be presented through the collection and analysis of Windows kernel and inside mechanisms, and through suggestions for the implementation methodologies of unreleased and new Windows kernel protection skill. Results presented in this paper will explain that the suggested system be highly effective and has more accurate for intrusion detection ratios, then the current legacy security systems (i.e., virus vaccines and Windows IPS, etc) intrusion detection ratios. So, It is expected that the suggested system provides a good solution to prevent IT infrastructure from complicated and intelligent Windows kernel attacks.