Multi-stacked HTS wires are needed to conduct large current in the power application. In this paper, magnetization losses of the multi-stacked YBCO wire and the BSCCO wire have been measured and compared. 4 types of YBCO wires and BSCCO wires, that is, single, 2-stacked, 3-stacked and 4-stacked, have been tested. HTS multi-stacked wires were fabricated using face-to-face type stacking method. Measurements of magnetization loss were performed under various angles of external magnetic field to consider the anisotropic characteristics of HTS wires. The ratios of the magnetization loss by multiple stacking of superconducting wires were presented. Measurements results show that loss reduction ratios have three distinct regions due to the magnitude of external magnetic field, the material of HTS wire and number of stacks.