Purpose: This study was to identify the effects of the application of elastic compression stockings during the hours of work on edema and pain of lower extremity in hospital nurses. Method: The participants were categorized into three groups, 15 for an experimental group of the application of Thigh-Length (T-L) elastic compression stocking, 15 for another experimental group of the application of Knee-Length(K-L) elastic compression stocking and 15 for a control group. The data were analyzed by $X^{2}-test$, ANOVA, Repeated Measures ANOVA and Sheffe-test using SPSS Win 12.0 program. Result: As a result of the study "There are significant differences in lower extremity edema among three groups." was partly supported. "There are significant differences in girth of ankle after work among three groups." was supported(Rt.:F=4.56, p=.016; Lt.: F=5.82, p=.006). "There are significant differences in girth of calf after work among three groups." was not supported(Rt. : F=1.76, p=.183; Lt. : F=1.94, p=.155) "There are significant differences in lower extremity pain after work among three groups." was supported(Rt. : F=95.33, p=.000; Lt. : F=81.33, p=.000). Conclusion: The results of this study revealed that the application of elastic compression stockings during the hours of work is effective for the relief of edema and pain of lower extremity in hospital nurses.