Topology optimization problem requires numerous repeated evaluations of objective function and design sensitivity for elements within design domain with various density distributions. The recently proposed two-level condensation scheme(TLCS) is very promising for the construction of reduced system and for an accurate and efficient analysis concerned about eigenvalue and dynamic problems. We used the two-level dynamic condensation scheme for the analysis and sensitivity computation part in the structural topology optimization problem. The results of the topology optimization for the reduced system show the TLCS provides high accuracy and computation efficiency compared to the full scale system within engineering accuracy.