Purpose: This study was conducted to examine the relationship among pain, family support, self-efficacy, depression of patients with arthritis. Method: The subjects of this study consisted of 96 patients with arthritis. The data was analyzed ANOVA. Duncan test. Pearson Correlation Coefficients using SAS. Result: Pain showed significant differences according to depression(F=8.12, p=0.001), self efficacy(F=11.52, p<.000) and not significant differences family support(F=0.34, p=0.714). There was a significant negative correlation between family support and depression(r=-.48, p<.000), depression and self efficacy(r=-.41, p<.000). Conclusion: Therefore, for the management of arthritis patient it is required continuous self-management and proper program on self-efficacy promotion.