FPSO and shuttle tanker are connected to each other by a mooring hawser and a loading hose through which cargo oil is off-loaded. Even in mild sea-state. environmental loads can cause unstable large drift motions between two vessels in tandem off-loading operations, which may result in collision incidents. Accordingly. the analysis on the relative motion between two vessels due to the environmental loads should be investigated in initial design stage. In this study, the low speed maneuvering equation is employed to simulate nonlinear motions of FPSO and shuttle tanker. Low frequency wave drift forces including hydrodynamic interactions between two vessels are evaluated by near field approaches. Current loads are determined by mathematical model of MMG and wind loads are calculated by employing the wind spectrum according to the guidelines of API-RP2A. Mooring forces produced by turret mooring lines and a flexible hawser are modeled quasi-statically by catenary equations. The effect of environmental loads that affect nonlinear motion is investigated through variation in their magnitudes and the nonlinear motions between FPSO and shuttle tanker are simulated under wave, current and wind in time domain.