Purpose: The purpose of this study was to describe the relationship between resilience and health-related quality of life and to identify the effect of resilience on health-related quality of life in children with chronic illness. Method: The participants in this study were 71 children who were seen at one of 3 hospitals, either in outpatient clinics or as admitted patients. The data were collected from March to October, 2005 and descriptive statistics, t-test or ANOVA, Pearson correlation coefficient and stepwise multiple regression were used to analyze the data. Result: Health-related quality of life was slightly low with a mean score of 2.85 (range 1-5). Health-related quality of life was significantly different according to age. There was a significant correlation between resilience and health-related quality of life. Resilience was a predictor of health-related quality of life and accounted for 45% of the variance. Conclusions: Resilience was shown to influence health-related quality of life of children with chronic illness. These findings suggest that the interventions to enhance resilience would be effective for the improvement of health-related quality of life.