Central Sericultural Research and Training Institute, Mysore have evolved several highly productive bivoltine hybrids which can produce international grade raw silk. Among them $CSR2{ imes}CSR4,;CSR2{ imes}CSR5,;CSR3{ imes}CSR6,;CSR17{ imes}CSR16,;CSR18{ imes}CSR19$ and $CSR12{ imes}CSR6$ are being popularized in the field. There is a minimum difference in their economic characters but they appear to differ in survival. Though they are productive under high input management conditions, they are very susceptible to different diseases under normal rearing practices. No systematic attempts have been made to test their susceptibility status / resistance. Thus the present study is a modest attempt to screen the above six productive bivoltine hybrids to two important pathogens viz., Bombyx mori Nuclear Polyhedrosis Virus (BmNPV) and Bombyx mori Infectious Flacherie Virus (BmIFV) along with existing hybrid, $KA{ imes}NB4D2$ to assess their susceptibility / resistance. The results shows that the productive hybrid $CSR2{ imes}CSR4$ is the most resistant to BmNPV and it is suggested by its highest $LC_{50}$ value followed by $CSR12{ imes}CSR6,;KA{ imes}NB4D2,;CSR3{ imes}CSR6,;CSR17{ imes}CSR16,;CSR18{ imes}CSR19,;CSR2{ imes}CSR5$. Based on the $LC_{50}$ value and $LT_{50}$ values for BmIFV, the hybrid $KA{ imes}NB4D2$ was found to be the most resistant (1st position) one followed by $CSR3{ imes}CSR6$ (2nd position) $CSR2{ imes}CSR$ (3rd position) and $CSR12{ imes}CSR6$ (4th position) $CSR17{ imes}CSR16$, $CSR18{ imes}CSR19$ (5th position) and $CSR2{ imes}CSR5$ being the least. The response of 7 bivoltine hybrids to both the pathogens BmNPV and BmIFV indicates that, the hybrids $CSR2{ imes}CSR4$, $CSR12{ imes}CSR6$ and $KA{ imes}NB4D2$ were found to be the most resistant when compared to others. Further, $KA{ imes}NB4D2$ being less productive hybrid with a shell ratio of 20.08%, the other two hybrids $CSR2{ imes}CSR4$ (Cocoon shell ratio, 21.44%) and $CSR12{ imes}CSR6$ (cocoon shell ratio, 23.45%) can be considered to be most productive with superior quality cocoon and resistant to both BmNPV and BmIFV pathogens. The overall study indicated that the hybrid $CSR2{ imes}CSR5$ is the most susceptible hybrid to both the pathogens.