This paper presents the Case of Systems Engineering Application for the Railway Total-Safety Project. Key points to consider for project are: 1) Establish the SE Based-Project organization system, 2) Define the SE Activities, 3) Manage technically the SE Based-Project, etc. They were of much help that the Railway Total-Safety Project which were efficiently implemented and managed. As I take it, the Systems Engineering is very reasonable approach for the systematical and technical conduct of a project.