In this letter, we propose a frame-size adaptive MAC protocol for high rate wireless personal area networks (WPANs). In the proposed scheme, during communication, frame error rate is periodically reported to a transmitting device and the frame size is changed according to the measured results. Thus, the channel can be more effectively utilized by adapting to variable radio conditions. Analytical results show that this scheme achieves a much higher throughput than a non-frame-size adaptive media access control protocol in high-rate WPANs.