This paper presents an application study of a model predictive control based commercial package PCTP to real chemical processes. The first case study concerns a product purity control of a splitter process which distillates styrene from undesired component ethyl-benzene produced from ethyl-benzene dehydrogenation reaction. The second case study is about a temperature control of ethyl-benzene dehydrogenation reactor and an excess oxygen control of the fired heater. Optimum control structure for MPC application is developed for each case study. The application results show a significant improvement in control performance and stability.