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국산 소나무껍질추출물(파인엑솔®)을 함유한 제제의 피부흡수 평가
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  • 국산 소나무껍질추출물(파인엑솔®)을 함유한 제제의 피부흡수 평가
저자명
최준호,최민구,한완택,한선정,정석재,심창구,김대덕,Choi. Joon-Ho,Choi. Min-Koo,Han. Ohan-Taek,Han. Sung-Jeong,Chung. Suk-Jae,Shim. Chang-Koo,Kim. Dae-D
간행물명
藥劑學會誌
권/호정보
2007년|37권 6호|pp.359-364 (6 pages)
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한국약제학회
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이 논문은 한국과학기술정보연구원과 논문 연계를 통해 무료로 제공되는 원문입니다.
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기타언어초록

Pine bark extract is well-known as a very powerful antioxidant, anti-inflammatory, and antibiotic material. French maritime pine bark extract ($Pycnogenol^{(R)}$) of Horphag Research has monopolized the world market over 30 years. Korean red pine bark extract ($Pinexol^{(R)}$) was first manufactured by the patent technology of NutraPharm in Korea in 2006. Feasibility of topical gel and patch formulations of Pinexol was systematically investigated by evaluating the skin absorption of catechin as a reference compound. In vitro hairless mouse skin absorption of catechin from gel formulation was higher than that from patches. However, significant amount of catechin was also deposited inside the skin from patch formulations, which were dependent on the types of pressure sensitive adhesives. Thus, it seems to be feasible to control the topical delivery of Pinexol by using both gel and patch formulations, and be necessary to conduct further systematic investigation.