This paper proposes the novel open-fault detection/isolation scheme of inverter switch in two-phase excited VSI. This scheme identify open-fault using voltage sensor at lower switches of each phase according to the operating mode. It has benefit of simple implementation, fast detection and robustness in the load so that stab of the system is improved. Also, at faulty mode, it minimizes faulty effect and makes possible continuous operation through the reconfiguration procedure applying four-switch operation. The validity of proposed fault detection scheme is verified by experimental results.