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수청바이러스의 M, L 분절의 염기서열 및 계통 분석
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  • 수청바이러스의 M, L 분절의 염기서열 및 계통 분석
저자명
김은주,문성실,송기준,송진원,박광숙,백락주,Kim. Eun-Ju,Moon. Sung-Sil,Song. Ki-Joon,Song. Jin-Won,Park. Kwang-Sook,Baek. Luck-Ju
간행물명
Journal of bacteriology and virology : JBV
권/호정보
2007년|37권 2호|pp.111-118 (8 pages)
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대한미생물학회
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이 논문은 한국과학기술정보연구원과 논문 연계를 통해 무료로 제공되는 원문입니다.
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기타언어초록

Hantaan virus (HTNV) and Seoul virus (SEOV) have mainly been known as the cause of hemorrhagic fever with renal syndrome (HFRS) in Korea since HTNV has been isolated from Korean field mouse, Apodemus agrarius in 1976 and SEOV has been isolated from Rattus norvegicus in 1980. Soochong virus-1, -2, -3, -4 (SOOVs) were isolated from lung tissues of four Apodemus peninsulae captured on August 1997 at Mt. Gyebang in Hongcheon-gun, Mt. Gachil, Inje-gun, Gangwon Province, and in September 1998 at Mt. Deogyu, Muju-gun, Jeollabuk Province. Apodemus peninsulae is the second-most dominant field rodent species found throughout Korea. To determine phylogenetic analysis of SOOVs, we entirely identified nucleotide sequences of M and L segments. The length of M segment was 3,615 bp and L segment was 6,533 bp. SOOVs were diverged from HTNV by $22.7{sim}23.3%$ and SEOV by $36.3{sim}37.2%$, in M segment. In addition, L segment was diverged from HTNV by $21.8{sim}22.0%$ and SEOV by $30.3{sim}30.5%$. SOOVs sequence compared with Amur virus (AMRV) in M segment showed that SOOVs were different with AMRV about $14.6{sim}16.2%$ in nucleotide sequences. Neighbor-joining phylogenetic analysis based on entire sequences of the M and L segment indicated that the SOOVs sequences present a separate lineage with HTNV, SEOV and AMRV. SOOVs constituted an individual cluster on the phylogenetic tree and they composed a phylogenic lineage separately. According to these data, SOOVs could be classified as a new hantavirus.