The objective of this work is to integrate reliability analysis into topology optimization problems. We introduce the reliability constraint in the topology optimization formulation, and the new model is called Reliability-Based Topology Optimization (RBTO). The application of the RBTO model gives a different topology relative to the classical topology optimization that should be deterministic. When comparing the structures resulting from the deterministic topology optimization and from the RBTO model, the RBTO model yields structures that are more reliable than the deterministic ones (for the same weight). Several applications show the importance of this integration.