Purpose: The purpose of this study was to investigate the relationship among aging anxiety, depression, and self-esteem of middle-aged people. Method: The study was designed as a descriptive correlation study Data were collected using a structured questionnaire which included general characteristics, and measures of aging anxiety, depression, and self-esteem. Data collection was done between March 15 and June 10. 2006 with 184 middle-aged participants. Results: The average score of the participants for aging anxiety was 48.38, for depression 16.49, and for self-esteem 29.08. There were positive correlations between aging anxiety and depression, aging anxiety and self-esteem. There was a negative correlation between depression and self-esteem. The correlations were statistically significant. Conclusion: Therefore, nursing program should be developed to improve the mental health and increase the qualitative life of middle-aged people.