This study reviewed the overall process of application of contaminant fate and transport model as part of risk assessment. Site characterization and establishment of a conceptual model prior to establishing or selecting a appropriate model were described. Types of models, model selection guidance, and generic site conditions for model application were presented, the process of model calibration, validation, and sensitivity analysis were reviewed. Objectives of modeling should be defined before model selection, and the complexity of selected models should balance the quantity and quality of available input data with the desired model output. If model output is highly sensitive to an assumed or default value of input parameter, or fate and transport models cannot be adequately calibrated or validated, consideration should be given to other options such as using measured data or using another model.