Topology optimization methods are classified into two methods such as the density method and the homogenization method. Those methods need to consider relationships between the material property and the density of each element in a design domain, the relaxation of the design space, etc. However, it is hard to apply on some cases due to the complexity to compose the design objective and its sensitivity analysis. In this paper, a modified topology optimization is proposed to assist designers who do not have mathematical or theoretical background of the topology optimization. In this study, optimal topology of structures can be achieved by the sequential design of experiment (DOE) and the sensitivity analysis. We conducted the DOE with an orthogonal array and the sensitivity analysis of design variables to determine sensitive variables used for connectivity between elements. The modified topology optimization method has advantages such as freedom from penalizing intermediate values and easy application with basic DOE concept.