The objective of this study was to investigate the validity of the digital ergonomic simulation (DES) method as a prospective alternative to the ergonomic analyses conducted by experts. The DES method utilizes commercial digital manufacturing software, and can compute the RULA scores continuously throughout the simulated work cycle. It was shown in a case study that the accuracy and objectivity of the DES method are superior to those obtained by experts. Also, it was demonstrated that the DES method has a distinct capability to simulate and validate a proposed work plan. Major limitations of the current DES method lie in the extensive time and efforts required for accurate digital simulation, which may be overcome through an automatic module for RULA data acquisition and a motion capture system.