MDO(Multidisciplinary Design and Optimization) can be applied for design of complex systems such as aircraft and SLV(Space Launch Vehicle). MDO System can be an integrated environment or a system, which is for synthetic and instantaneous analysis and design optimization in various design fields. MDO System has to efficiently use and integrate distributed resources such as various analysis codes, optimization codes, CAD, DBMS, GUI, and etc. in heterogeneous environments. In this paper, we present Web Services-based MDO System that integrates resources for MDO using Globus Toolkit and provides organic autonomous execution using automation technique such as Workflow system and agent. And also, it provides collaborative design environment through web user interfaces