In digital radiography, to improve the contrast of digital radiography image, the multi-scale nonlinear amplification algorithm based on unsharp masking is one of the major image enhancement algorithms. In this paper, we used the Laplacian pyramid to decompose a digital radiography(DR) image. In our simulation, the DR image was decomposed into seven layers and the coefficients of the each layer was amplified with nonlinear function. We also imported a noise containment algorithm to limit noise amplification. To enhance the contrast of image, we proposed a new adaptive non-linear gain amplification coefficients. As a result of having applied to some clinical data, a detail visibility was improved significantly without unacceptable noise boosting. Images that acquired with the proposed adaptive non-linear gain coefficients have shown superior quality to those that applied similar gain control method and expected to be accepted in the clinical applications.