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최적선형필터를 이용한 망막신경절세포 Spike Train으로부터의 시각자극 세기 변화 추정
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  • 최적선형필터를 이용한 망막신경절세포 Spike Train으로부터의 시각자극 세기 변화 추정
저자명
류상백,김두희,예장희,김경환,구용숙,Ryu. Sang-Baek,Kim. Doo-Hee,Ye. Jang-Hee,Kim. Kyung-Hwan,Goo. Yong-Sook
간행물명
Journal of biomedical engineering research : the official journal of the Korean Society of Medical & Biological Engineering
권/호정보
2007년|28권 2호|pp.212-217 (6 pages)
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이 논문은 한국과학기술정보연구원과 논문 연계를 통해 무료로 제공되는 원문입니다.
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기타언어초록

As a preliminary study for the development of electrical stimulation strategy of artificial retina, we set up a method fur the reconstruction of input intensity variation from retinal ganglion cell(RGC) responses. In order to estimate light intensity variation, we used an optimal linear filter trained from given stimulus intensity variation and multiple single unit spike trains from RGCs. By applying ON/OFF stimulation(ON duration: 2 sec, OFF duration: 5 sec) repetitively, we identified three functional types of ganglion cells according to when they respond to the ON/OFF stimulus actively: ON cell, OFF cell, and ON-OFF cell. Experiments were also performed using a Gaussian random stimulus and a binary random stimulus. The input intensity was updated once every 90 msec(i. e. 11 Hz) to present the stimulus. The result of reconstructing 11 Hz Gaussian and binary random stimulus was not satisfactory and showed low correlation between the original and reconstructed stimulus. In the case of ON/OFF stimulus in which temporal variation is slow, successful reconstruction was achieved and the correlation coefficient was as high as 0.8.