The methanol extract of Coscinium fenestratum, commonly own as tree turmeric, which is widely used in the indigenous system of medicine was studied for its in vitro scavenging activity in different methods viz DPPH scavenging, nitric oxide scavenging, iron chelation activity, superoxide scavenging, ABTS radical scavenging and lipid peroxidation. The results were analyzed statistically by regression method. Its antioxidant activity was estimated by $IC_{50}$ value and the values are $57.1;{mu}g/ml$ for DPPH radical scavenging, $36.5;{mu}g/ml$ for iron chelating activity, $51.7;{mu}g/ml$ for nitric oxide scavenging, $53.63;{mu}g/ml$ for ABTS scavenging, $44.2;{mu}g/ml$ for superoxide scavenging, and $40;{mu}g/ml$ for lipid peroxidation. In all the methods, the extract showed its ability to scavenge free radicals in a concentration dependent manner. The results indicate that C. fenestratum has potent antiofidant activity.