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Synergism in Antifungal Activity against Candida and Trichophyton Species in Combination with the Essential Oil of Coriandrum sativum L. and Antibiotics
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  • Synergism in Antifungal Activity against Candida and Trichophyton Species in Combination with the Essential Oil of Coriandrum sativum L. and Antibiotics
  • Synergism in Antifungal Activity against Candida and Trichophyton Species in Combination with the Essential Oil of Coriandrum sativum L. and Antibiotics
저자명
Lim. Sook,Shin. Seung-Won
간행물명
Natural product sciences
권/호정보
2007년|13권 1호|pp.85-89 (5 pages)
발행정보
한국생약학회
파일정보
정기간행물|ENG|
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이 논문은 한국과학기술정보연구원과 논문 연계를 통해 무료로 제공되는 원문입니다.
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기타언어초록

To determine whether the essential oil from Coriandum sativum and its main component, linalool, exhibit antifungal activity, we employed a broth dilution assay and disk diffusion test using common pathogenic Candida and Trichophyton species. Both coriander oil and linalool significantly inhibited growth of the tested fungi, with minimal inhibitory concentrations (MICs) in the range of $0.03{sim}2mg/ml$. Furthermore, in a checkerboard titer test, both the oil fraction and linalool exhibited synergism when combined with ketoconazole, with resultant FICIs ranging from 0.06 to 0.53. Notably, hyphal formation in C. albicans cells was obviously inhibited by C. sativum essential oil in this experiment.