For the past few years, the concern for clean energy has been greatly increased. Ocean Thermal Energy Conversion(OTEC) power plants are studied as a viable option for the supply of clean energy. In this paper, the thermodynamic performance of OTEC cycle was examined. Computer simulation programs were developed under the same condition and various working fluids for closed Rankine cycle, regeneration cycle, Kalina cycle, open cycle and hybrid cycle. The results show that the regeneration cycle using R125 showed a 0.17 to 1.56% increase in energy efficiency, and simple Rankine cycle can generate electricity when the difference in warm and cold sea water inlet temperatures are greater than $15^{circ}C$. Also, the cycle efficiency of OTEC power plant using the condenser effluent from nuclear power plant instead of the surface water increased about 2%.