Objectives: The purpose of this report is to examine the effect of $BL_{66}$ ${cdot}$ $GB_{43}$ supplement and LIl ${cdot}$ $GB_{44}$ draining in acupuncture for cerebral apoplexy treatment. Methods : I designed to investigate whether $BL_{66}$ ${cdot}$ $GB_{43}$ supplement and $LI_1$ ${cdot}$ $GB_{44}$ draining in acupuncture affects cerebral hemodynamics [regional cerebral blood flow(rCBF), mean arterial blood pressure(MABP)] in normal rats, and to make manifest whether $BL_{66}$ ${cdot}$ $GB_{43}$ supplement and $LI_1$ ${cdot}$ $GB_{44}$ draining in acupuncture is mediated by cyclooxygenase or guanylate cyclase. The changes of rCBF and MABP were determinated by laser-doppler flowmetry(LDF). Results : 1. $BL_{66}$ ${cdot}$ $GB_{43}$ supplement and LI1 ${cdot}$ $GB_{44}$ draining in acupuncture increased rCBF significantly, but decreased MABP. These results suggest that $BL_{66}$ ${cdot}$ $GB_{43}$ supplement and $LI_1$ ${cdot}$ $GB_{44}$ draining in acupuncture increased significantly rCBF by dilating pial arterial diameter(PAD). 2. By pretreatment with indomethacin(1 mg/kg, i.p.), the effect of $BL_{66}$ ${cdot}$ $GB_{43}$ supplement and $LI_1$ ${cdot}$ $GB_{44}$ draining in acupuncture induced increase of rCBF was significantly inhibited, the decreased MABP by treatment with $BL_{66}$ ${cdot}$ $GB_{43}$ supplement and $LI_1$ ${cdot}$ $GB_{44}$ draining in acupuncture was increased. 3. By pretreatment with methylene blue($10{mu}/kg$, i.p.), the increased rCBF by treatment with $BL_{66}$ ${cdot}$ $GB_{43}$ supplement and $LI_1$ ${cdot}$ $GB_{44}$ draining in acupuncture was decreased conversely, the decreased MABP by treatment with $BL_{66}$ ${cdot}$ $GB_{43}$ supplement and $LI_1$ ${cdot}$ $GB_{44}$ draining in acupuncture was decreased. and then increased. Conclusion : I suggest that $BL_{66}$ ${cdot}$ $GB_43$ supplement and $LI_1$ ${cdot}$ $GB_{44}$ draining in acupuncture has an anti-ischemic effect through the improvement of cerebral hemodynamics.