Objects : This study was designed to determine origin-plants of 3 kinds of Scrophulariaceae herbs reported worldwide 220 families 3000 species, domestic 21 families 55 species by researching efficacy of each herb. Furthermore the objects of study were confirmation of genuine species and substitution species standing on the results. Methods : In this studies, the origin-plants and efficacy were determined by bibliographic method. Results : The results indicate that 1. There were total 15 species of original plants of Scrophulariaceae herbs, 9 species for Radix Scrophulariae, 4 species for Radix Rehmanniae Recens, 2 species for Rhizoma Picrorrhizae. 2. In the view of authenticity of Radix Scrophulariae, there were 2 genuine species, 1 species for substitution, and study of 6 species later on. 3. In the view of authenticity of Radix Rehmanniae Recens, there were 2 genuine species, 1 species for substitution, and study of 1 species later on. 4. In the view of authenticity of Rhizoma Picrorrhizae, all the original species was genuine species. 5. The each efficacy of origin-plants were reported in the main subject. Conclusions : The 15 original plants were present among the 3 medicinal herbs in the common family scrophul ariaceae. There were 2 genuine species in Radix Scrophulariae and Rhizoma Picrorrhizae. All the original species was genuine species in Rhizoma Picrorrhizae.