Background : Dandruff is a chronic scalp condition characterized by scaling. The common causative agent is now accepted to be the lipophilic Pityrosporum ovale. Obstecive : We conducted a randomized, double-blind, parallel-group study to investigate the efficacy of Herbal Shampoo & Essense and placebo in patients with mild to moderate dandruff. Mathods : Forth-seven patients with dandruff were assigned to one of two treatment goups: Test (contaning the medication) or control (vehicle). After administering through randomizion, two groups were used with Negative sampoo for first two weeks, and used with test or control products for second two weeks. Results : 1. After 2 weeks of treatment, the numbers of P. ovale in test groups were decreased in a statistically meaningful way(p<0.01) compared with control groups. 2. After 2 weeks of treatment, average of sebum-amount in test groups were decreased from 117.55 to 92.88, in a statistically meaningful way(P<0.05, paired t-test) compared with control groups that were decreased from 115.53 to 112.46. 3. In clinical score, average of control groups is decreased from 2.82 to 1.09. on the other sides, average of test groups is decreased from 3.88 to 2.44. The change of test groups is bigger than that of control groups, both two groups was decreased in a statistically way(<0.01) Conclusion : The study demonstrated that Herbal Shampoo & Essense can be used by patients with scalf safely and effectively with almost no side-effect.