Recently, high-rise base isolated building structures with shear keys are often constructed in Japan which frequently occurs earthquakes. High-rise buildings are less damaged because those buildings have longer natural period than md or low rise buildings. The shear key is device that prevents the base isolators operating by the wind loads not by the earthquake loads. In case of big base shear force acts on the shear keys by earthquake, this device is broken and base isolator is operated. Therefore, seismic intensities play a role in acting on the shear keys. If wind loads are hither than the earthquake loads, the shear keys designed by wind loads are not operated in earthquakes. So, the requirements of shear keys in high-rise base isolated building structures must be examined in Korea with moderate seismic legions. In this study shear keys are applied with 5 and 15 stories base isolated building structures and investigated their dynamic responses to original and 1/2 scale downed El Centre NS(1940) ground motions. The results show that the yield shear forces of the shear keys affect significantly the dynamic behavior of base isolated building structures