This paper introduces an optimal design technique for a 250-watt isolation transformer using an optimization method, dynamic encoding algorithm for searches (DEAS). Although the optimal design technique for transformers dates back to 1970s and various optimization methods have been developed so far, literature concerning global optimization for transformer core design is rarely found against its importance. In this paper, core configuration of the isolation transformer whose performance is computed by complex mathematical steps is optimized with DEAS. The optimization result confirms that DEAS can be successfully employed to transformer core design for various performance specifications only by adjusting weight factors in cost function.