Purpose: This study was performed to identify factors affecting the functional status in disabled persons in the Jeiu Province. Method: Data were collected from 318 disabled persons in the Jeiu province during the period from the 6th of July to the 11th of October in 2006. The functional status was assessed by the disability assessment schedule II (Whodas II) of the World Health Organization and collected data were analyzed using the SAS 8.0 program. Result: The mean score of WHODAS II was 29.9. According to the results of multiple regression, factors affecting the functional status were perceived health condition(t=3.44, p<.001), brain disorder disability(t=2.55, p<.001), treatment status(t=-1.95, p=.05), drinking(t=2.09, p=.04), stress(t=-2.72, p=.01), depression(t=-2.70, p=.01). heart disease(t=2.62. p=.01) and anemia(t=2.20, p=.03). Conclusion: The functional status was affected by health behaviors, diseases, and the type of disability. Thus, future efforts to promote the functional status of disabled persons may need to take into account all these factors.