The collision avoidance maneuver flight simulation for tilt rotor unmanned aerial vehicle was performed by time-accurate numerical integration method based on wind tunnel test data. Five representative collision avoidance maneuvers were simulated under constraints of aerodynamic stall, propulsion power, structural load, and control actuator capability. The collision avoidance performances of the maneuvers were compared by the computed collision avoidance times. The sensitivities of initial flight speed and collision zone shape on the collision avoidance time were investigated. From these results, it was found that the moderate pull-up turn maneuver defined using moderate pitch and maximum roll controls within simulation constraints is the most robust and efficient collision avoidance maneuver under the various flight speeds and collision object shapes in the tilt rotor UAV applications.