Semiconductor manufacturing is one of the most complex and capital-intensive processes composed of several hundreds of operations. In today’s competitive business environments, it is more important than ever before to manage manufacturing process effectively to achieve better performances in terms of customer satisfaction and productivity than those of competitors. So, many semiconductor manufacturing companies implement advanced planning and scheduling (APS) system as a management tool for the complex semiconductor manufacturing process. In this study, we explain roles of production planning and scheduling in semiconductor manufacturing and principal factors that make the production planning and scheduling more difficult. We describe the APS system implementation project at Korean semiconductor manufacturing company in terms of key issues with realistic samples.