For the purpose of understanding the feature of earlier prescriptions before Jeonhan-era(前漢時期), we invastigated "Osibi-byeongbang Jeobyeong(五十二病方 疽病)" and come to the follwing conclusions. 1. Hwanggi and Baeglyeom were combined in many cases of prescriptions. And Warming and Heating herbs such as Gye(桂), Gang(薑), Cho(椒) are the main herbs in combination of the herbs and adjusting the portions. 2. Out of inspection of the Current prescriptions of Jeobyeong(疽病), we find that the remedies were very diverse at that time. There are the synthetic methods of expelling toxin from within the body method, elimination from within method, sweat-inducing method, replenish Eum and Heat-reducing method. 3. The principles of combinations of prescriotions in "Osibi-byeongbang Jeobyeong(五十二病方 疽病)"are simple and have obvious orientations in remedies.