Nowadays, in our country, large vacuum chambers for huge experimental facilities such as the tokamak fusion device, high power neural beam test stand, and space simulator have been constructed. In such a vacuum chamber of very large size, it is quite complicate to check on leakage quantitatively, while the probability of a leak is relatively high. To investigate the feasibility of applying reliably a helium leak detection to the huge vacuum chambers, and to find a reasonable methodology of choosing an optimum set-up for leak detection, several virtual constructions of the leak detection system have been analyzed by calculating the pressure distribution in the system and the helium level in the sensor part.