Weight reduction for automobile components has been sought to achieve fuel efficiency and energy conservation. There are two approaches in reducing their weights. One is by using material lighter than steel, and the other is by redesigning their structures. The latter has been performed by adopting hydroforming, tailor weled blank, optimization, etc. In this research, the kriging approximation method and simulated annealing algorithm are applied to the design of a front door made by TWB (Tailor Welded Blank) technology. The design variables are set up as the thicknesses of parts and the positions of parting lines. A thickness set considered as a design variable of each part is not arbitrarily determined but selected from standard products, so it is a discrete set. This research presents the discrete and continuous structural optimization method for an automotive door design.