In this study, we conducted a vibration fatigue analysis of the lower control arm in a vehicle suspension system. The vehicle was driven during the tests so that the dynamic effects could be taken into account. The dynamic load of the frequency domain was superimposed on the frequency response analysis. We performed a virtual proving ground test using multi-body dynamics, along with a finite element analysis and fatigue life predictions. Shape optimization was also considered using the design of the experimental approach, and a response surface analysis was performed to improve the durability performance of the lower control arm. We identified the elements that had the most influence on the optimal shape of the finite element model and analyzed the sensitivity of those elements. Then the optimal points that minimized the amount of damage to the areas of interest were determined through a response surface analysis. The results suggested that the fatigue life of the model increased as its mass was not increased excessively, and demonstrated that these design procedures yielded an appropriate optimized lower control arm model.