A multi-agent and web based engineering framework concerning the automation of fatigue durability analysis for welded bogie frame of railway vehicles is presented. Mostly, this kind of design or analysis includes complex workflow, huge amounts of information processing, and problem solving. Macro programs of I-DEAS, APDL of ANSYS, and in-house fatigue code are utilized for parametric geometry representation, automatic mesh generation, static stress analysis, fatigue durability analysis, post-processing, and data sorting. The engineering framework is implemented on the JADE. Since every task requires a fairly complex process and specialized knowledge, the multi-agent based framework is very useful to keep the independency among several disciplines or tasks and to use distributed hardware and software resources. All engineering programs are integrated by XML wrapper. Related database of the engineering framework and web based user interfaces are also developed. A parametric study is carried out to take into account the effect of geometrical change of transom support bracket on its cumulative fatigue damage. The developed engineering framework reduced remarkably the time and costs required in designing and solving engineering problems.