Objectives: This study aims to identify the usage status of general drugs by some college students based on their own judgment and the relevant factors having impact on them. Methods: The questionnaire survey was conducted by visiting the students in 3 colleges in Daejeon and Chungcheongnam-Do. 792 students were finally selected as the subjects. The results were statistically analyzed using the SPSSWIN(ver 13.0) and $x^2-test$, ANOVA and multiple regression analysis were conducted. Results: The usage status of college students showed the significant difference by general features, knowledge and recognition attitude. The knowledge level of students on the general drugs was very low. They had excessive expectation on the general drugs in terms of the recognition attitude. The lowest factor was the distrust on the general drugs. 27.5% of subjects was satisfied with the effect after using 48.1%m when the drugs were frequently used. Those who experienced the side effects accounted for 9.6%. In accordance with the analysis on the factors related to the knowledge on, recognition attitude on and usage status of general drugs, the education had the highest influence on the abuse and misapplication of drugs. For the mistrust factor on the drugs and negligence factor on abnormal response, the gender was the most influencing. The knowledge level was the greatest impact on the excessive expectation factor on the drugs. The factor that the usage status was the most influential was the education on the abuse and misapplication of drugs. Conclusions: The systematic approach including establishment of health policies for the improvement of health and health education activity should be implemented on the basis of the thorough analysis on the knowledge level and recognition on drugs and the factors influencing on the usage of drugs.