In control of the time delay systems, if the disturbance information can be estimated exactly, the ideal response for the disturbance can be achieved. Therefore, in this paper, a new adaptive disturbance observer for the time delay system control is proposed. The disturbance observer is designed and adaptive laws for adjusting the observer are proposed. The new Smith predictor controller to eliminate the effects of the disturbance can be achieved by adding an estimated disturbance to the Smith model. The improved performances of the proposed system and the adaptive disturbance observer are verified by computer simulation.