The high speed machining has been widely applied to manufacture dies and machine elements in industrial field. Especially, 5-axis milling has been employed to produce a wide range of turbine blades, impellers and complex molds. In this study, the machining characteristics of injection molds were investigated according to tool tilting angles in 5-axis milling. The cutting force and surface roughness were investigated with various tool tilting angles. When the tool tilting angle was over than 10 degree, the characteristics of cutting force and surface roughness were improved in machining of Al alloy.