The integration method of binary and real encoding in genetic algorithm is proposed to deal with design variables of various types in gear drive design. The method is applied to optimum design of multi-stage gear drive. Integer and Discrete type design variables represent the number of teeth and module, and continuous type design variables represent face width, helix angle and addendum modification factor etc. The proposed genetic algorithm is applied for the gear ratio optimization and the volume optimization(minimization) of multi-stage geared motor which is used in field. In result, the proposed design optimization method shows an effectiveness in optimum design process and the new design has a better results compared with the existing design.