This paper considers acoustic characteristics of silencer within a dry vacuum pump. The main objective is to reduce noise in dry vacuum pump using the new designed silencer. First, SPL and sound intensity are measured for noise source identification and the new model silencer is designed corresponding to noise characteristics. 4-pole parameters are used to predict the transmission loss which is one of the interest characteristics of the new silencer. The calculated transmission loss is then used to change main effective factor and optimal value is selected by using design of experiment. By conducting an experiment, it is proved that the new designed silencer has reduced noise level by 6 dB(A) more than the original one.