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Influence of Water Soluble Additives and HPMCP on Drug Release from $Surelease^{circledR}-coated$ Pellets Containing Tamsulosin Hydrochloride
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  • Influence of Water Soluble Additives and HPMCP on Drug Release from $Surelease^{circledR}-coated$ Pellets Containing Tamsulosin Hydrochloride
  • Influence of Water Soluble Additives and HPMCP on Drug Release from $Surelease^{circledR}-coated$ Pellets Containing Tamsulosin Hydrochloride
저자명
Kim. Min-Soo,Kim. Jeong-Soo,Kang. Sun-Ho,Yoo. Yeon-Hee,Lee. Si-Beum,Park. Jeong-Sook,Woo. Jong-Soo,Hwang. Sung-Joo
간행물명
Archives of pharmacal research : a publication of the Pharmaceutical Society of Korea
권/호정보
2007년|30권 8호|pp.1008-1013 (6 pages)
발행정보
대한약학회
파일정보
정기간행물|ENG|
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기타
이 논문은 한국과학기술정보연구원과 논문 연계를 통해 무료로 제공되는 원문입니다.
서지반출

기타언어초록

The objective of this study was to investigate the influence of various water-soluble additives and HPMCP as an enteric polymer into $Surelease{circledR}$ for the development of oral controlled release system containing tamsulosin hydrochloride. The drug loaded pellets were coated with only $Surelease{circledR}$ or $Surelease{circledR}$ containing HPMC, PEG 4000, mannitol and HPMCP (20% w/w). In case of HPMC and PEG 4000 as additives into $Surelease{circledR}$ film, the rapid drug release was observed in pH 1.2 while the higher drug release was achieved by adding HPMCP into $Surelease{circledR}$ as well as by increasing the amount of HPMCP (10, 20, and 30% w/w) in pH 7.2. The incorporation of HPMCP into $Surelease{circledR}$ showed pH-dependent drug release due to its pH-dependent nature. Therefore, the incorporation of HPMCP into $Surelease{circledR}$ based on aqueous coating formulation is an effective way to develop oral controlled release delivery systems containing tamsulosin hydrochloride.