12,13-Dihydroxyfumitremorgin C, Fumitremorgin C, and Brevianamide F, Antibacterial Diketopiperazine Alkaloids from the Marine-Derived Fungus Pseudallescheria sp.

12,13-Dihydroxyfumitremorgin C, Fumitremorgin C, and Brevianamide F, Antibacterial Diketopiperazine Alkaloids from the Marine-Derived Fungus Pseudallescheria sp.

ㆍ 저자명: Zhang. Dahai,Noviendri. Dedi,Nursid. Muhammad,Yang. Xiu-Dong,Son. Byeng-Wha
ㆍ 간행물명: Natural product sciences
ㆍ 권/호정보: 2007년|13권 3호|pp.251-254 (4 pages)
ㆍ 발행정보: 한국생약학회
ㆍ 파일정보: 정기간행물|
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ㆍ 주제분야: 기타

이 논문은 한국과학기술정보연구원과 논문 연계를 통해 무료로 제공되는 원문입니다.

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기타언어초록

Dioxopiperazine alkaloids, 12R,13S-dihydroxyfumitremorgin C (1), fumitremorgin C (2), and brevianamide F (3), were isolated from the marine-derived fungus Pseudallescheria, and the absolute stereostructures of compounds 1 - 3 were elucidated on the basis of chemical and physicochemical evidence. Compounds 1 - 3 showed an antibacterial activity against Staphylococcus aureus, methicillin-resistant S. aureus, and multidrug-resistant S. aureus. The MIC (minimum inhibitory concentration) values of compounds 1 - 3 were 125 ${mu}g/mL$ for all strains.

키워드

Marine-derived fungus Pseudallescheria sp 12 13-dihydroxyfumitremorgin C fumitremorgin C brevianamide F antibacterial activity

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