In this paper, we suggest GP operators based on tree structure considering tree distributions in structure space and structural difficulties. The main idea of the proposed genetic operators is to place generated offspring into the specific region which nodes and depths are balanced and most of solutions exist. To enable that, the proposed operators are designed to utilize region information where parents belong and node/depth rates of selected subtree. To demonstrate the effectiveness of our proposed approach, experiments of binomial-3 regression, multiplexer and even parity problem are executed. The experiments results show that the proposed operators based on tree structure is superior to the results of standard GP for all three test problems in both success rate and number of evaluations.