The high-order numerical method based on the adaptive mesh refinement(AMR) on the quadrilateral unstructured grids has been developed in this paper. This adaptive-grid method, originally developed with MUSCL-TVD scheme, is now extended to the WENO (weighted essentially no-oscillatory) scheme with the Runge-Kutta time integration of fifth order in spatial and temporal accuracy. The multidimensional interpolation was studied in the preliminary research, which allows us to maintain the same order of accuracy for the computation of numerical flux between two adjacent cells of different levels. Some standard benchmark tests are done to validate this method for checking the overall capacity and efficiency of the present adaptive-grid technique.