Vehicle vibration mostly originates from the road excitation and causes discomfort, fatigue and even injury to a driver. Vehicle ride comfort is one of the most important performance indices to achieve a high-quality vehicle design. Since design parameter variations inevitably result in the vehicle ride comfort variance, the variance characteristics should be analyzed in the early design stage of the vehicle. The vehicle ride comfort is often defined by an index which employs a weighted RMS value of the acceleration PSD of a seat position. The design solution is obtained through two steps in this study. An optimization problem to obtain a minimum ride comfort index is solved first. Then another optimization problem to obtain minimum variance of the ride comfort index is solved. For the optimization problems, the equations of motion and the sensitivity equations are derived basing on a 5-DOF vehicle model. The numerical results show that an optimal solution for the minimum ride comfort is not necessarily same as that of the minimum variance of the ride comfort.