Epidermoid cysts can be found anywhere in the body, particularly in areas where embryonic elements fuse together. Most cases have been reported in the ovaries, the testicles, as well as the hand and feet. Epidermoid cysts in mouth are uncommon and account for less than 0.01% of all oral cysts. The treatment of choice is complete surgical excision and prognosis is excellent. The purpose of this article is to describe two cases of an epidermoid cyst in the oral cavity mucosa and a review of the literature.