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생강나무 추출물의 항산화 활성과 미백효과
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  • 생강나무 추출물의 항산화 활성과 미백효과
  • Antioxidant Activities and Whitening Effect from Lindera obtusiloba BL. Extract
저자명
방채영,원은경,박권우,이광원,정세영,Bang. Chae-Young,Won. Eun-Kyung,Park. Kuen-Woo,Lee. Gwang-Won,Choung. Se-Young
간행물명
약학회지
권/호정보
2008년|52권 5호|pp.355-360 (6 pages)
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대한약학회
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정기간행물|
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이 논문은 한국과학기술정보연구원과 논문 연계를 통해 무료로 제공되는 원문입니다.
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기타언어초록

In this study we investigated antioxidant activity of against several free radicals and skin whitening effect of 70% ethanol extract (leaf extracts and branch/stem mixed) of Lindera obtusiloba BL. Antioxidant activity was assessed by DPPH, superoxide radical and hydroxyl radical assays. The Lindera obtusiloba BL. extract had antioxidant activity dose dependently with an ${IC}_{50}$ value of 243.14 and 181.10 ${mu}g$/ml for DPPH, 165.77 and >1500 ${mu}g$/ml for non-enzymatic system of superoxide radical assay, 35.47 and >100 ${mu}g$/ml for enzymatic system of superoxide radical assay, 1.21 mg/ml for hydroxyl radical assay. In addition we tested tyrosinase inhibition activity and melanin contents on B16 melanoma F10. B16 melanoma cell was treated by such sample as 1, 5, 10 and 50 ${mu}g$/ml for 72 hr and tyrosinase inhibition was tested. Melanogenesis was inhibited to 22% at the dose of 50 ${mu}g$/ml and tyrosinase was inhibited to 45.2% at the same dose. In conclusion Lindera obtusiloba BL had potent antioxidant activity and inhibitory activity of tyrosinase and melanin formation. It could be developed as the health functional food and functional cosmetic resources.